Moderate dose of hydroxyurea in children with sickle cell disease and stroke. Preliminary results.
| Dublin Core | Elementos de metadatos PKP | Metadatos para el documento | |
| 1. | Título | Título del documento | Moderate dose of hydroxyurea in children with sickle cell disease and stroke. Preliminary results. |
| 2. | Creador/a | Nombre de autor/a, institución, país | Sergio Machín-García; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Andrea Menéndez Veitía; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Claudio Sherle Matamoros; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Eva Svarch; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Alberto Arencibia Núñez; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Adys Gutíerrez Díaz; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Tania García Peralta; Cuba |
| 2. | Creador/a | Nombre de autor/a, institución, país | Rosa Lam Díaz; Cuba |
| 3. | Materia | Disciplina(s) | |
| 3. | Materia | Palabra/s clave | Sickle cell disease, stroke, hydroxyurea, chronic transfusion. |
| 4. | Descripción | Resumen |
Twenty children with sickle cell anemia, two with SC hemoglobinopathy and one with S/β0 thalassemia were treated, with a previous stroke or abnormal ultrasound transcranial Doppler (TCD) flow velocities more than 170 cm/s. The mean follow-up was of 41 ± 19 months. Hydroxyurea (HU) at a dose of 25 mg/kg/day associated with chronic transfusion therapy, was administrated during one year to patients with stroke. Patients with abnormal TCD received only HU at the same dose. There was a significant decrease of stroke (p <0.02) and TCD flow velocities in the right middle cerebral artery (p <0.003). It was necessary to associate chronic transfusion therapy in three children with high velocities in TCD without stroke, due to the lack of response to the treatment with HU. The combination of HU and transfusions during one year can be useful for stroke therapy and prevention. |
| 5. | Editorial | Institución organizadora, ubicación | Editorial Ciencias Médicas |
| 6. | Colaborador/a | Patrocinador(es) | |
| 7. | Fecha | (DD-MM-AAAA) | 2013-09-10 |
| 8. | Tipo | Estado y género | Artículo revisado por pares |
| 8. | Tipo | Tipo | |
| 9. | Formato | Formato de archivo | HTML |
| 10. | Identificador | Identificador uniforme de recursos | http://revhematologia.sld.cu/index.php/hih/article/view/99 |
| 11. | Fuente | Título; vol., núm. (año) | Revista Cubana de Hematología, Inmunología y Hemoterapia; Vol. 30, No. 1 (2014): Enero - Marzo |
| 12. | Idioma | Español=es | en |
| 13. | Relación | Archivos complementarios | |
| 14. | Cobertura | Localización geoespacial, periodo cronológico, muestra de investigación (sexo, edad, etc.) | |
| 15. | Derechos | Derechos de autor/a y permisos |
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