Prevalence of hemophilia in six cuban provinces

Dunia Castillo-González, Roberto Lardoeyt-Ferrer, Delfina Almagro-Vázquez, Rosa M Lam-Díaz, Kalia Lavaut-Sánchez, Adys Gutierrez-Díaz, Mirtha Campo-Díaz, Nereyda Alvarez-Vega, Jorge Luis Salinas-González, Julio Fernández-Aguila, Olga Agramonte-Llanes

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Introduction: Hemophilia is an inherited bleeding disorder; its incidence is almost constant in different populations. Since the 80th decade a multidisciplinary group for the care of patients with hemophilia was created at the Instituto de Hematología e Inmunología.  Nowadays a national comprehensive care program allows patients to receive a continuous monitoring and an effective treatment. Objective: To know prevalence of patients with hemophilia in Cuba.  Results: Data of 229 patients from 5 provinces and the special municipality Isla de la Juventud were included, which covered 58,71% of the total patients registered in Cuba. The information included demographic data, severity of hemophilia, presence of inhibitors and infection status for viral diseases. Hemophilia A patients were 188 (82.10 %) and 41 (17.90 %) with hemophilia B.   The disease was severe in 56.33 % of patients, moderate in 24 %, and mild in 19.70 %. Inhibitors were present in 17.03 % of the patients. Human immunodeficiency virus infection was present only in 0.87 % of patients and hepatitis C virus infection in 39.03 %. The mean age at diagnosis was 2.15 years. Conclusions: The general age-adjusted prevalence was 9.63 cases of hemophilia per 100 000 male and the main prevalence of patients was found in ages between 20 and 59 years.

Palabras clave

haemophilia, epidemiology, prevalence, Cuba

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