Disseminated intravascular coagulation and sepsis: treatment and diagnostic criteria

Authors

Keywords:

sepsis, disseminated intravascular coagulation, anticoagulants, diagnosis, therapy.

Abstract

Introduction: Sepsis is a pathological process characterized by inordinate inflammation which may cause severe coagulopathies, such as disseminated intravascular coagulation. This coagulopathy is mainly characterized by exposure of the tissue factor, activating the coagulation cascade and generating a prothrombotic state which may worsen organ failure.

Objective: Analyze diagnostic criteria and therapeutic implications to present an update on the management of patients with disseminated intravascular coagulation and sepsis.

Methods: A search was conducted for papers published in the databases PubMed, Science Direct and SciELO, using the search terms coagulopathy, sepsis, disseminated intravascular coagulation, diagnostic criteria and treatment.

Conclusion: Improvement was observed in the mortality of patients treated with anticoagulants such as protein C and antithrombin, among others. However, these findings have not achieved the relevance required to be recommended for inclusion in the treatment guides for disseminated intravascular coagulation.

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Published

2020-12-28

How to Cite

1.
Martínez-Sanchéz LM, Mercado Avendaño G. Disseminated intravascular coagulation and sepsis: treatment and diagnostic criteria. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2020 Dec. 28 [cited 2025 Mar. 14];36(4). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1214

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Section

Artículos de Revisión