Characterization of adult patients with diffuse large B-cell non-Hodgkin lymphoma

Authors

Keywords:

diffuse large B-cell lymphoma, overall survival, disease-free survival.

Abstract

Introduction: Diffuse large B-cell lymphoma is the most common subtype of aggressive non-Hodgkin lymphoma.

Objective: Characterize the behavior of adult patients with diffuse large B-cell lymphoma.

Methods: An observational retrospective longitudinal descriptive study was conducted of 56 adult patients with diffuse large B-cell lymphoma attending the Institute of Hematology and Immunology from January 1998 to December 2018.

Results: Of the patients studied, 55.4% were male, and a predominance was found of white skin color (76.8%) and the 59-78 years age group (44.6%). Patients with comorbidities prevailed, mainly hypertension (35.7%) with an ability to perform activities of daily living (55.4%). 53.6% of the patients were in stage IV at diagnosis. Patients with type B symptoms prevailed with 85.7%, and the low to intermediate risk group was the most common with 35.7%. The regimen most frequently used was R-CHOP, obtaining 85.7% complete remission. 17.9% of the patients died and 41.1% relapsed. Overall survival at 3, 5 and 10 years was 87.0%, 83.0% and 80.0%, respectively. Disease-free survival at 3, 5 and 10 years was 74.0%, 67% and 56%, respectively.

Conclusions: Overall and disease-free survival were high.

Author Biographies

Yamilé Quintero Sierra, Instituo de Hematología e Inmunología

Especialista de 2do Grado en Hematología

Especialista de 1er Grado en Medicina General Integral

Máster en enfermedades infecciosas

Profesora Instructor e Investigador Auxiliar

Miembro de la Sociedad Cubana de Hematología

Carlos Hernández Padrón, Instituto de Hematología e Inmunología

Doctor en Ciencias Médicas

Especilaista de 2do Grado en Hematología

Profesor Titular e Investigador Auxiliar

 Miembro de la Sociedad Cubana de Hematología

Yusleidy Concepción Fernández, Instituto de Hematología e Inmunología

Especialista de 1er Grado en MGI

Especialista de 1er Grado en Hematología

Investigador Agregado

Miembro de la Sociedad Cubana de Hematología

Adrián Romero González, Instituo de Hematología e Inmunología

Especialista de 1er Grado en MGI

Especialista de 2do Grado en Hemnatología

Profesor Auxiliar

Investigador Auxiliar

Miembro de la Sociedad Cubana de Hematología

Ivis Macia Pérez, Instituto deHematología e Inmunología

Especialista de 1er Grado en MGI

Especialista de 1er Grado en Hematología

Miembro de la Sociedad Cubana de Hematología

Rosa María Lam, Instituto deHematología e Inmunología

Especialista de 1er Grado en MGI

Especialista de 1er Grado en Bioestadística

Published

2020-12-28

How to Cite

1.
Quintero Sierra Y, Hernández Padrón C, Concepción Fernández Y, Romero González A, Macia Pérez I, Lam RM. Characterization of adult patients with diffuse large B-cell non-Hodgkin lymphoma. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2020 Dec. 28 [cited 2025 Jan. 31];36(4). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1225

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