Scope of stem cells derived from adipose tissue

Authors

Keywords:

lipotransfer, mesenchymal stem cells, stromal vascular fraction, regenerative therapy.

Abstract

Introduction: Mesenchymal stem cells with self-renewing and multipotential capacity have been identified in adipose tissue. By means of enzymatic digestion and centrifugation of the lipoaspirate a heterogeneous population of cells called vascular stromal fraction is released. It has innumerable therapeutic potentialities in the field of regenerative medicine.

Objective: To update the scope of stem cells derived from adipose tissue in regenerative therapy.

Method: 38 articles published between 2000 and 2019 in the Scielo, ScienceDirect, Medline and Pubmed databases were reviewed.

Development: The cells of the vascular stromal fraction are characterized by generating adipose tissue and blood vessels and by the production of growth factors that help in the survival of adipocytes and the formation of a vascular network. The main mechanism of action of stem cells derived from adipose tissue appears to be due to their paracrine action and synergy with endothelial cells. Stem cells derived from adipose tissue have been used in regenerative medicine for the treatment of pathological scars and deforming fibrosis with functional impotence, in the reconstruction of cancer sequelae and in the early closure of bloody areas.

Conclusions: Lipotransfer is a procedure with a minimum of complications that constitutes one of the most widely used therapeutic options to correct tissue defects, since it is not only a filling medium, but also allows tissue regeneration and restoration. The presence of stem cells in adipose tissue, together with their accessibility, availability and histocompatibility, has motivated their increasingly widespread application in aesthetic, reconstructive and regenerative medicine.

 

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Author Biographies

Alicia María Tamayo Carbón, Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. La Habana, Cuba.

MEDICO ESPECIALISTA SEGUNDO GRADO JEFE DE SERVICIO  CIRUGIA PLASTICA RECONSTRUCTIVA Y CAUMATOLOGIA PROFESOR ASISTENTE INVESTIGADOR AUXILIAR

Heizel Escobar Vega, Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. La Habana, Cuba.

MEDICO ESPECIALISTA SEGUNDO GRADO  CIRUGIA PLASTICA RECONSTRUCTIVA Y CAUMATOLOGIA PROFESOR E INVESTIGADOR AUXILIAR

Diana Katherine Cuastimal Figueroa, Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. La Habana, Cuba.

MEDICO RESIDENTE PRIMER AÑO CIRUGIA PLASTICA RECONSTRUCTIVA Y CAUMATOLOGIA

Published

2021-05-31

How to Cite

1.
Tamayo Carbón AM, Escobar Vega H, Cuastimal Figueroa DK. Scope of stem cells derived from adipose tissue. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2021 May 31 [cited 2025 Jul. 11];37(2). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1237

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Section

Artículos de Revisión