Homologous Platelet lysate as astimulatinghealing factor for the grafts donor area

Authors

Keywords:

wound healing, platelet lysate, bloody area, autologous graft.

Abstract

Introduction: The search for treatment alternatives that allow reducing wound healing and hospitalization time are fundamental aspects in research nowadays. Platelet growth factors are capable of enhancing wound healing.

Objective: Determine the benefits of applying homologous platelet lysate on the donor area of autologous skin graft.

Methods: A prospective longitudinal-section study was conducted in 20 patients with bloody areas that required autologous skin graft at the “Hospital Hermanos Ameijeiras” between August 2016 and May 2019. Two graft intakes were made in the same patient and anatomical region, one of them treated with platelet lysate (intervention zone) and one with conventional treatment (control zone). Patients selection was intentional. Absolute numbers and proportions were used to study the qualitative variables, and measures of central tendency and dispersion were used in the quantitative variables. To compare de results, the Friedman test was applied, setting a level of significance p < 0,05.

Results: The main cause of bloody area was burns (75 %), the most affected age group was those over 55 years, the healing percentage was greater in the intervention group with a statistically significant shorter epithelization time (p < 0,01) and there was less pain in the intervention zone. There were no complications.

Conclusions: The benefits found in the intervened area with platelet lysate were significant with faster healing and less pain.


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Author Biographies

Luz Marina Miquét Romero, Hospital Clínico Quirúrgico “Hermanos Ameijeiras.” La Habana, Cuba.

Médico especialista de II grado en Cirugía Plástica y Caumatología, profesor e Investigador Auxiliar. Máster en nutrición.

Alicia María Tamayo Carbón, Hospital Clínico Quirúrgico “Hermanos Ameijeiras.” La Habana, Cuba.

Médico especialista de II grado en Cirugía Plástica y Caumatología, profesor asistente e investigador auxiliar, jefe de servicio Cirugía Plástica y Quemados.

Daniel Alfredo Posada Ruiz, Hospital Clínico Quirúrgico “Hermanos Ameijeiras.” La Habana, Cuba.

Médico Residente de Cirugía Plástica y Caumatología

Manuel Alejandro Orozco Jaramillo, Hospital Clínico Quirúrgico “Hermanos Ameijeiras.” La Habana, Cuba.

Médico Residente de Cirugía Plástica y Caumatología

Susel Paola Sánchez, Hospital Clínico Quirúrgico “Hermanos Ameijeiras.” La Habana, Cuba.

Médico especialista de I grado en Cirugía Plástica y Caumatología

Mayra Cecilia Hernández Collado, Hospital Clínico Quirúrgico “Hermanos Ameijeiras.” La Habana, Cuba.

Médico especialista de I grado en Cirugía Plástica y Caumatología. Profesor asistente.

Published

2021-05-31

How to Cite

1.
Miquét Romero LM, Tamayo Carbón AM, Posada Ruiz DA, Orozco Jaramillo MA, Sánchez SP, Hernández Collado MC. Homologous Platelet lysate as astimulatinghealing factor for the grafts donor area. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2021 May 31 [cited 2025 May 12];37(2). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1261

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Artículos Originales