Cytomegalovirus in hematopoietic stem cell transplant recipients

Authors

  • Juan Carlos Jaime Fagundo Instituto de Hematología e Inmunología
  • Wilfredo Roque García Instituto de Hematología e Inmunología
  • Leónides Castellanos Hernández Universidad de Pamplona, Colombia

Keywords:

cytomegalovirus, cytomegalic disease, hematopoietic transplantation, immunosuppression, ganciclovir, letermovir

Abstract

Introduction: Cytomegalovirus infection is very common in patients undergoing hematopoietic progenitor transplantation, due to myeloablative conditioning treatments, genetic disparity, and immunosuppressive treatment, and occurs mainly after the engrafment. Objective: A review and update of the diagnosis and management of cytomegalovirus is made in hematopoietic transplant recipients. Method: A bibliographic review was carried out in Spanish and English, using the search engines of Pubmed, Scholar Google and Scielo about the diagnosis and management of cytomegalovirus in hematopoietic transplant recipients. Development: The information obtained was collected and organized chronologically about the emergence of techniques for diagnosis and the appearance of new drugs in recent years. Recent articles by experts in prestigious journals were reviewed and the importance of early diagnosis and initiation of treatment is evidenced. Conclusions: There are currently new forms of diagnosis and novel medications, but mortality can be high, if the patient is not treated before the symptoms of the disease appear and even despite treatment, sometimes it is not possible to eradicate the virus, leading to major complications and death. Cytomegalic disease continues to be a frequent complication in these patients despite measures to prevent virus reactivation.
 

Author Biographies

Juan Carlos Jaime Fagundo, Instituto de Hematología e Inmunología

Especialista II Grado en Hematogía; Profesor  e Investigador auxiliar. Jefe del Servicio de Transplante Hematopoyético del Instituto de Hematología e Inmunología; Miembro de la Junta de Gobierno de la Sociedad Cubana de Hematología. Editor principal del sitio web de Hematología

Wilfredo Roque García, Instituto de Hematología e Inmunología

Especialista I Grado en Hematogía; Profesor  e Investigador auxiliar.

Published

2021-04-06

How to Cite

1.
Jaime Fagundo JC, Roque García W, Castellanos Hernández L. Cytomegalovirus in hematopoietic stem cell transplant recipients. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2021 Apr. 6 [cited 2024 Dec. 27];37(1). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1279

Issue

Section

Artículos de Revisión

Most read articles by the same author(s)

1 2 3 4 > >>