Hemorrhagic cystitis and giant condyloma acuminatum of anus in a receptor of haploidentical hematopoietic transplant

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Keywords:

hemorrhagic cystitis, anus condiloma acuminatum, bone marrow transplant, haploidentical hematopoietic transplant

Abstract

Introduction: The reactivations of latent virus after bone marrow transplants affect the outcome of these patients. Hemorrhagic cystitis caused by BK virus, constitute a frequently lethal complication characterized by abdominal pain, hematuria and renal damage. The incidence is between 13-70 % in hematopoietic transplant receptors. The management includes antibiotics, antivirals, hyperhydration and forced diuresis, platelets and hyperbaric oxygen. Condyloma acuminatum of the anus associated to human papillomavirus is rare among transplanted patients (0.3-1.3 %). It is characterized by an invading mass in the region of the anus producing pain and bleeding. The treatment of choice is the surgical resection of the tumor.

Objectives: To describe the clinical characteristics and evolution of hemorrhagic cystitis and anal condyloma acuminatum in a receptor of haploidentical hematopoietic transplant.

Discussion: A 20-year-old man with diagnosis of acute myeloid leukemia, on day +21 post-transplant presented macroscopic hematuria associated to BK virus reactivation and resolved with hyperbaric oxygen. On day + 59 post-transplant, anal pain started and a perianal, cauliflower-like mass over 5 cm, was observed. He was diagnosed with condyloma acuminatum of the anus and surgical resection was successfully performed.

Conclusions: We reported a unique case of concurrence of both, hemorrhagic cystitis and condyloma acuminatum of the anus after haploidentical hematopoietic transplant. The proper management of these two pathologies allowed a satisfactory evolution of the patient.

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Published

2021-04-06

How to Cite

1.
Roque García W, Jaime Fagundo JC, Sarduy Sáez S. Hemorrhagic cystitis and giant condyloma acuminatum of anus in a receptor of haploidentical hematopoietic transplant. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2021 Apr. 6 [cited 2025 Jan. 11];37(1). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1298

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