CD5 positive Diffuse large B cell lymphoma with prostate involvement: An unusual recurrence

Authors

Keywords:

Lymphoma, Lymphoma Non-Hodgkin, CD5 Antigens, Recurrence, Prostate.

Abstract

Introduction: CD5 positive Large B-cell Lymphoma (CD5 + DLBCL) constitutes a rare and aggressive pathology with poor response to chemoimmunotherapy.

Objective: To describe a case with a diagnosis of CD5 + DLBCL with an unusual recurrence in the prostate.

Clinical case: A 61-year-old male presented abdominal pain and B symptoms. Imaging studies showed mediastinal and retroperitoneal lymphadenopathy. The pathology informed a CD5+ DLBCL diagnosis, receiving first-line R-CHOP treatment and achieving complete remission, with prostatic early relapse confirmed by immunohistochemistry. Therefore, he received R-ICE as rescue treatment with poor response and performance status decline.

Conclusions: CD5 + LDCGB represents a rare and aggressive disease, being the prostate relapse a very unusual event, in which the exhaustive clinical and pathological workup is essential for an accurate diagnosis. To date, the response to standard or higher-intensity therapies is disappointing, so more studies are needed in the future.

 

 

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Author Biography

Deisy Shudey Tarazona López, Privado

Médico cirujano, especialista en oncología médica, con experiencia en investigación, docencia y asistencial.

Published

2021-11-22

How to Cite

1.
Castro Uriol DA, Tarazona López DS, Mendoza Choque R, Beltrán Garate BE. CD5 positive Diffuse large B cell lymphoma with prostate involvement: An unusual recurrence. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2021 Nov. 22 [cited 2025 Apr. 4];37(4). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1384

Issue

Section

Presentaciones de casos