Acute myeloid leukemia: prognostic influence of some biomarkers and the therapeutic response in patients under 60 years of age

Authors

Keywords:

acute myeloid leukemia, prognosis, biomarkers.

Abstract

Introduction: Acute myeloid leukemia is a clonal disease, recognized as one of the most heterogeneous malignant hemopathy in which certain clinical, immunological, cytogenetic and molecular biomarkers influence the response of patients to treatment.

Objective: Describe the prognostic influence of immunological, cytogenetic and molecular biomarkers on the therapeutic response in adult patients under 60 years of age with acute myeloid leukemia.

Methods: An exhaustive review was conducted about the topic in the databases as Pubmed, Scielo, ScienceDirect, Medline and Scholar Google, for which papers mainly published in the last five years were used as reference.

Analysis and synthesis of the information: The immunological, cytogenetic and molecular heterogeneity of adult patients under 60 years of age with acute myeloid leukemia is related to the variability in the response to treatment that patients have and affects their overall and disease-free survival.

Conclusions: Based on the immunological, cytogenetic and molecular characteristics, it is possible to establish the prognosis of patients with acute myeloid leukemia, which allows selecting the appropriate therapy to reduce complications, relapses as much as possible and increase overall survival.

 

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Author Biographies

Yamile Quintero Sierra, Instituto de Hematología e Inmunología. La Habana, Cuba.

Especialista de 1er y 2do grado en Hematología Especialista de 1er grado en Medicina General Integral Master en enfermedades infecciosas Profesora e Investigador Auxiliar Miembro de la Sociedad Cubana de HEmatología

Carlos Hernández Padrón, Instituto de Hematología e Inmunología. La Habana, Cuba.

Doctor en Ciencia médicas Especialista de 2do grado en Hematología Profesor Titular Investigador Auxiliar

Yusleidy Concepción Fernández, Instituto de Hematología e Inmunología. La Habana, Cuba.

Especialista de 1er grado en MGI Especialista de 1er grado en Hematología Profesor Asistente Investigador Agregado

Published

2021-07-23

How to Cite

1.
Quintero Sierra Y, Hernández Padrón C, Concepción Fernández Y. Acute myeloid leukemia: prognostic influence of some biomarkers and the therapeutic response in patients under 60 years of age. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2021 Jul. 23 [cited 2025 Aug. 2];37(3). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1455

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Section

Artículos de Revisión