Reactivation of brucellosis in an autologous hematopoietic transplant recipient: a case report

Authors

Keywords:

brucellosis, hematopoietic transplantation, immunosuppression, Hodgkin's disease.

Abstract

Introduction: Brucellosis is the most frequent zoonosis, produced by the genus brucella, which affects several species of mammals, including human beings.  It is transmitted to persons by direct contact with infected animals, by their excreta or by ingestion of unpasteurized products. In recent years, an increase has been described in immunocompromised patients.

Objectives: To describe the reactivation of brucellosis in a hematopoietic transplant recipient patient, its course and management.

Case presentation: A patient with Hodgkin's lymphoma and a history of brucellosis is presented; that she received a myeloablative autologous hematopoietic transplant. After haematological recovery, she started with symptoms of fever, diaphoresis, joint pain and hepato-splenomegaly. She was diagnosed with brucellosis, so treatment with doxycycline and rifampin was started, which eliminated the symptoms and made the evolutionary tests negative.

Conclusions: Brucellosis can be asymptomatic for months or years and after immunosuppression it can be reactivated in transplanted patients. Suspicion and prompt treatment can bring about a cure and avoid complications.

 

Author Biographies

Juan Carlos Jaime Fagundo, Instituto de Hematología e Inmunología

Especialista II Grado en Hematogía; Profesor e Investigador Auxiliar. Jefe del Servicio de Transplante Hematopoyético del Instituto de Hematología e Inmunología; Miembro de la Junta de Gobierno de la Sociedad Cubana de Hematología. Editor principal del sitio web de Hematología

Wilfredo Roque García, Instituto de Hematología e Inmunología

Especialista I Grado en Hematogía; Profesor Asistente e Investigador Agregado. Servicio de Transplante Hematopoyético

Yamilé Quintero Sierra, Instituto de Hematología e Inmunología

Especialista I Grado en Hematogía; Profesor Asistente e Investigador Agregado. Servicio de Adulos

Francisco Valdés Cabrera, Instituto de Hematología e Inmunología

Servicio de Pediatría. Profesor asistente

Leónides Castellanos Hernández, Universidad de Pamplona. Colombia

Profesor Asistente

Published

2022-04-12

How to Cite

1.
Jaime Fagundo JC, Roque García W, Quintero Sierra Y, Valdés Cabrera F, Castellanos Hernández L. Reactivation of brucellosis in an autologous hematopoietic transplant recipient: a case report. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2022 Apr. 12 [cited 2025 Jan. 11];38(2). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1575

Issue

Section

Presentaciones de casos

Most read articles by the same author(s)

1 2 3 4 5 6 7 > >>