Venous thromboembolic disease in hematologic malignancies: a preventive approach

Authors

  • Agnerys López Sacerio Hospital Universitario “Arnaldo Milián Castro”. Villa Clara https://orcid.org/0000-0001-8020-9186
  • Wilfredo Torres Iribar Servicio de Hematología. Hospital Clínico Quirúrgico Hermanos Ameijeiras. La Habana, Cuba. https://orcid.org/0000-0001-5644-8689
  • Javier Cruz Rodríguez .Hospital Universitario “Arnaldo Milián Castro”. Servicio de Cirugía General Villa Clara.

Keywords:

venous thromboembolic disease, hematologic malignancies.

Abstract

Introduction: Venous thromboembolic disease is a frequent complication in hematologic malignancies with incidence similar to that observed in solid tumors with high thrombotic risk. Objective: To describe the influence of risk factors and biomarkers of venous thromboembolic disease associated with hematologic malignancies and their application in the design of risk assessment models for the prevention of this disease.

Methods: An exhaustive review was carried out in the specialized literature of articles published on the subject using the following databases: PubMed, SciELO, ScienceDirect, Medline and the academic Google search engine.

Analysis and synthesis of the information: Multiple risk factors for the occurrence of venous thromboembolism have been described in patients with hematologic malignancies: patient-related, disease-related, treatment-related and molecular, as well as biomarkers of risk. Based on these, several investigations have been developed to elaborate and validate predictive venous thromboembolism models to guide risk stratification and prophylactic treatment of venous thromboembolic disease in hematologic malignancies, although they are still insufficient. Lymphomas and multiple myeloma have more research in this area than other hematologic malignancies.

Conclusion: There is a need to design new risk models and validate existing ones in a larger number of cases, as well as to develop prospective studies in patients at risk of thromboembolic events and hematologic malignancies, to carry out a personalized primary prevention strategy with thromboprophylaxis stratification.

 

Author Biographies

Agnerys López Sacerio, Hospital Universitario “Arnaldo Milián Castro”. Villa Clara

Especialista de I Grado en Hematología y MGI

Profesor Asistente e Investigador agregado

Wilfredo Torres Iribar, Servicio de Hematología. Hospital Clínico Quirúrgico Hermanos Ameijeiras. La Habana, Cuba.

Doctor en Ciencias, Profesor titular, especialista de segundo grado de Hematología y  Laboratorio Clínico

Javier Cruz Rodríguez, .Hospital Universitario “Arnaldo Milián Castro”. Servicio de Cirugía General Villa Clara.

Doctor en Ciencias, Investigador Auxilar, Master en Urgencias Médicas. Profesor Instructor. Especialista de 1grado en MGI y Cirugía General

Published

2022-06-02

How to Cite

1.
López Sacerio A, Torres Iribar W, Cruz Rodríguez J. Venous thromboembolic disease in hematologic malignancies: a preventive approach. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2022 Jun. 2 [cited 2024 Dec. 18];38(2). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1620

Issue

Section

Artículos de Revisión