Estimation of glomerular filtration rate using serum creatinine and cystatin C in adults with sickle cell anemia

Authors

Keywords:

sickle cell anemia, chronic renal failure, glomerular filtration rate, cystatin C.

Abstract

Introduction: The estimation of the glomerular filtration rate from the serum concentration of creatinine in patients with sickle cell disease is abnormal when there is an extensive deterioration of renal function. Objective: To estimate the glomerular filtration rate with the use of creatinine, cystatin C and both determinations, in adults with sickle cell disease. Determine if there are differences between these methods. Methods: Observational, descriptive cross-sectional study. Forty-four adults with sickle cell disease were included in whom the glomerular filtration rate was estimated using creatinine, cystatin C and both, according to the CDK-EPI formulas. Results: Discrepancies were found in the glomerular filtration rate estimated by creatinine, by cystatin C and by both (means: 112.2 ± 28.4; 55.7 ± 23.1 and 75.1 ± 24.7 mL/min/1.73 m2; respectively). The highest percentages of patients with creatinine hyperfiltration correspond to the SS genotype and all those with stage 4 chronic kidney disease (estimated filtration by cystatin C and by the combination of both markers), have this type of hemoglobinopathy. Hyperfiltration was more common in the youngest and decreased filtration in those older than 40 years. Conclusions: The estimation of the glomerular filtration rate shows differences between the three methods studied. With the use of creatinine, it is overestimated and a high proportion of patients are classified as having hyperfiltration. The use of cystatin C or the combination of both determinations could offer a more accurate estimate of glomerular filtration rate in patients with sickle cell disease.

Author Biographies

Julio Dámaso Fernández Águila, Hospital General Universitario "Dr. Gustavo Aldereguía Lima", Cienfuegos.

Especialista de II Grado en Hematología, Profesor Asistente, Investigador Auxiliar. Máster en Ensayos Clínicos. Jefe del Servicio de Hematología del HGU Dr. Gustavo Aldereguía Lima. Miembro y Presidente del Capítulo Provincial de la Sociedad Cubana de Hematología. Miembro de la Junta de Gobierno de la Sociedad Cubana de Hematología.  Miembro de Sociedad Cubana de Farmacología.

Yamila Rodríguez Jiménez., Universidad de Ciencias Médicas. Cienfuegos

Especialista I Grado en Medicina Genral Integral y en Bioquímica Clínica. Profesor Instructor

Pedro Sánchez Frenes, Banco de Sangre Provincial de Cienfuegos

Especialista II Grado en Laboratorio Clínico. Dr en Ciencias de Salud. Máster en Salud Pública. Profesor Auxiliar. Investigador Agregado

Marta Patricia Casanova González, Hospital General Universitario "Dr. Gustavo Aldereguía Lima", Cienfuegos.

Especialista de II Grado en Nefrología. Máster en Enfermedades Infecciosas. Profesora Asistente

Claudia Tamara Fernández González, Hospital General Universitario "Dr. Gustavo Aldereguía Lima", Cienfuegos

Especialista de I grado en Medicina Interna. Servicio de Hematología.

Flora Amanda Fernández Villares, Universidad de Ciencias Médicas. Cienfuegos

Estudiante de quinto año  de Medicina. Alumna Ayudante de Hematología

Published

2022-11-28

How to Cite

1.
Fernández Águila JD, Rodríguez Jiménez. Y, Sánchez Frenes P, Casanova González MP, Fernández González CT, Fernández Villares FA. Estimation of glomerular filtration rate using serum creatinine and cystatin C in adults with sickle cell anemia. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2022 Nov. 28 [cited 2024 Dec. 5];38(4). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1736

Issue

Section

Artículos Originales

Most read articles by the same author(s)

1 2 > >>