Platelet/lymphocyte and neutrophil/lymphocyte indices as predictors of infection in preterm pregnants with premature rupture of membranes

Authors

  • Alexander Javier Ramos Velastegui
  • Diego Eduardo Guato Canchinia
  • Edisson Vladimir Maldonado Mariño

Keywords:

premature rupture of membranes, preterm, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, histopathological diagnosis

Abstract

Introduction: Premature rupture of membranes (PRM) is a very common obstetric problem. Platelet/lymphocyte (PLI) and neutrophil/lymphocyte (INL) indices are being studied as possible predictors of infection in patients with PRM, which may contribute to the prevention of complications associated with PRM.

Objective: To evaluate the usefulness of the IPL and INL as predictors of infection in preterm pregnancies with PRM at the Alfredo Paulson Hospital, in Ecuador, between 2018 and 2020.
Methods: An observational, retrospective and cross-sectional study was carried out, framed in an epidemiological design, which was supported by the Chi-Square test. The study population was 70 patients with PRM.

Results: Ten patients had a higher risk by spending more than 4 days with PRM. In 11 there were complications and a long hospital stay (more than 8 days). Patients with compromised fetal well-being and cesarean sections predominated. 80% reported some degree of infection such as amnionitis, chorionitis and chorioamnionitis. On admission, the INL and IPL were high in 82.86% and 44.29%, respectively. Significant differences were found between patients with high values for these tests and those who had a positive histopathological diagnosis for infection.
Conclusions: The INL is correlated with the histopathological result as an early marker of infection, while the IPL is a marker of commitment or presence of sepsis, which puts the life of the mother and the fetus at risk.

Published

2023-06-19

How to Cite

1.
Ramos Velastegui AJ, Guato Canchinia DE, Maldonado Mariño EV. Platelet/lymphocyte and neutrophil/lymphocyte indices as predictors of infection in preterm pregnants with premature rupture of membranes. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2023 Jun. 19 [cited 2025 Jan. 31];39(1). Available from: https://revhematologia.sld.cu/index.php/hih/article/view/1914

Issue

Section

HEMATOLOGÍA