Infomed

Biblioteca Virtual de Salud Universidad Virtual de Salud

ISSN 1561-2996

Vol. 36 No. 3 (2020): julio - septiembre

Current Issue

Vol. 36 No. 3 (2020): julio - septiembre

Published: 2020-12-04

Editorial

Myeloid chronic leukemia: a treatment paradigm in oncohematology

Adrián Romero González

Artículos de Revisión

Myelodysplastic syndromes: beyond hypomethylating agents

Norma Fernández Delgado, Hany Janet Trujillo Puentes
Diagnosis, classification and treatment of acute leukemia of ambiguous lineage

Vianed Marsán Suárez, Gabriela Díaz Domínguez, Yenisey Triana Marrero
Introduction: Acute leukemias of ambiguous lineage constitute a heterogeneous group of acute leukemias that do not show clear evidence of differentiation along cell lineage. The definitive diagnosis is made exclusively based on immunophenotypic characteristics, with the use of multiparametric flow cytometry. Objective: To update the diagnostic criteria, classification, as well as the clinical and therapeutic management of acute leukemias of ambiguous lineage. Methods: A search for scientific information related to the subject was carried out in clinical hematology textbooks and in articles published through PUBMED in the last ten years. An analysis and summary of the revised bibliography was carried out. Information analysis and synthesis: The morphological characteristics of the leukemic cells from patients with acute leukemia of ambiguous lineage do not show uniformity. Blasts of different sizes and stages of maturation can be found simultaneously. These may appear as lymphoid, myeloid, undifferentiated, or mixed. Conclusion: Acute leukemias of ambiguous lineage constitute a high-risk subgroup, with unfavorable prognosis and poor overall patient survival. Its timely report is essential to gather criteria for making therapeutic decisions in this group of patients.

Heidys Garrote Santana
Hereditary hemolytic anemias due to defective globin synthesis

Gilberto Soler Noda, Mariela Forrellat Barrios
Sideroblastic anemia, a rare disease of multiple causes

Lina Maria Martinez Sanchez, Santiago Castañeda Palacio

Artículos Originales

Frequency of molecular disorders in Cuban patients with acute myeloid leukemia

Ana María Amor Vigil, Londy Lorena Hernández Miranda, Carmen Alina Díaz Alonso, Vera Ruiz Moleón, Lesbia Fernández Martínez, Ignacio Oliva Hernández, Heidys Garrote Santana
Design and optimization of a polychromatic tube of flow cytometry for peripheral lymphocyte immunophenotype

Yaima Zúñiga Rosales, Carlos Villegas Valverde, Bárbara Torres Rives, Evelyn Hernández Reyes
A professional upgrading program in transfusion medicine for the specialty of anesthesiology and resuscitation

Ubaldo Roberto Torres Romo, Neyda Fernández Franch, Arturo Teodoro Menéndez Cabezas, Sarah Estrella López Lazo, Sandra López Lamezón

Comunicaciones Breves

Cytogenetics of malignant hemopathies in the sequencing era

Kalia Lavaut Sánchez

Presentaciones de casos

Allogenic hematopoietic stem-cell transplantation in aplastic anemia: the first case report in Cuba

Aliette García García, Calixto Hernández Cruz, José Carnot Uria, Kali Cepero Llauger, Ibis Karina Pardo Ramirez, Leidy Allué Flores
Cardiac amyloidosis secondary to Waldenström macroglobulinemia

Lizbeth Lachira Yparraguirre, Ali Al-kassab Córdova, Edgar Quispe Silvestre, Daniel Jair Enriquez Vera